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BCSJ Award Article (2010) The Bulletin of the Chemical Society of Japan, Vol. 83 (No. 1-12)
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2010 Vol. 83 Jan. |
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19-32 |
Catalytic Enantioselective Alkylation and Arylation of Aldehydes by Using Grignard Reagents |

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Y. Muramatsu, S. Kanehira, M. Tanigawa, Y. Miyawaki, and T. Harada*
[Full Text PDF(J-STAGE)] [Supporting Information] Free Access Article
Grignard reagents can be used in enantioselective alkylation and arylation of aldehydes by using chiral titanium(IV) catalysts in the presence of titanium tetraisopropoxide. The reaction proceeds with a low catalyst loading, exhibiting high enantioselectivity for various Grignard reagents and aldehydes.
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